PIFA-promoted intramolecular oxidative C(aryl)-H amidation reaction: Synthesis of quinolino[3,4- b ]quinoxalin-6(5 H )-ones

Autor:	Chunfang Hu, Qingfeng Liu, Guisheng Zhang, Tongxin Liu, Zhiguo Zhang, Wenjing Gao
Rok vydání:	2018
Předmět:	010405 organic chemistry Aryl Organic Chemistry Oxidative phosphorylation 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Intramolecular force Drug Discovery Molecule
Zdroj:	Tetrahedron. 74:665-671
ISSN:	0040-4020
Popis:	A facile and direct intramolecular oxidative C(aryl)-H amidation reaction was developed for the synthesis of quinolino[3,4-b]quinoxalin-6(5H)-ones in moderate to excellent yields starting from readily available materials by tethering the adjacent N-methoxyamide and aryl portions in the presence of phenyliodine(III) bis(trifluoroacetate) at room temperature. This metal-free approach is a valuable addition to the traditional methods already available for the preparation of these molecules.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c767f780c358d7db884a2d3c808c65f5 https://doi.org/10.1016/j.tet.2017.12.016 Zobrazit plný text záznamu Full Text from ScienceDirect