Fabrication of novel bifunctional nanohybrid based on layered rare-earth hydroxide with magnetic and fluorescent properties
| Autor: | Qingyang Gu, Rongyue Zhang, Ruijun Ju, Haibo Jin, Liangshuo Ji, Jinyan Li |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Magnetism Intercalation (chemistry) Sulforhodamine B 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Drug detection chemistry.chemical_compound chemistry Chemical engineering Drug delivery General Materials Science 0210 nano-technology Bifunctional Luminescence Drug carrier human activities |
| Zdroj: | Frontiers of Materials Science. 14:488-496 |
| ISSN: | 2095-0268 2095-025X |
| Popis: | We demonstrate the fabrication of a novel magnetic nanohybrid involving the drug molecule 5-aminolevulinic acid (5-ALA) intercalated Gd-Eu layered rare-earth hydroxide (LRH) coated on magnesium ferrite particles (MgFe2O4). The structure, thermostability, morphology, luminescence properties, cytotoxic effect and magnetism are investigated. The 5-ALA intercalated composite may correspond to a monolayered vertical arrangement, and the thermal stability of organics is enhanced after intercalation. The LRH precursor shows red emission of Eu3+ and the maximum emission peak of the composite is at 451 nm, corresponding to the blue emission. The detection of drug molecules can be realized through the change of luminescence. The magnetic nanohybrid shows strong magnetic sensitivity, which provides an easy and efficient way to separate 5-ALA-MgFe2O4@LGd0.95H:Eu0.05 particles from a sol or a suspension system and to carry drugs to targeted locations under an external magnetic field. The cytotoxic effect of MgFe2O4@LRH is observed with a sulforhodamine B (SRB) colorimetric assay, which has low cytotoxic effects on selected cells. The fabrication of novel bifunctional drug carriers based on LRH with magnetic and fluorescent properties has potential applications in drug detection and drug delivery. |
| Databáze: | OpenAIRE |
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