A Comparison of Thiothixene with Chlorpromazine in the Treatment of Mania
| Autor: | Philip G. Janicak, Joseph E. Comaty, C. Malinick, D. B. Bresnahan, Rajiv P. Sharma, J. M. Davis |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Lithium (medication) Side effect business.industry medicine.drug_class medicine.medical_treatment Psychiatry and Mental health chemistry.chemical_compound Thiothixene chemistry Anesthesia Sedative mental disorders Medicine Potency Pharmacology (medical) medicine.symptom business Psychiatry Antipsychotic Chlorpromazine Mania medicine.drug |
| Zdroj: | Journal of Clinical Psychopharmacology. 8:33 |
| ISSN: | 0271-0749 |
| DOI: | 10.1097/00004714-198802000-00006 |
| Popis: | High potency neuroleptics have been advocated for acute mania because their side effect profile may allow for a more rapid dose escalation and symptom resolution. Low potency neuroleptics have also been advocated because their sedative properties might better calm the acutely agitated manic patient. The authors tested these hypotheses using a double-blind design comparing thiothixene with chlorpromazine in 29 manic patients on a standard dose of lithium. They found that thiothixene and chlorpromazine produced identical rates and degree of improvement, that side effect profiles differed for each drug but did not affect overall clinical response, and that most patients had a good response on much lower than expected doses. The implications for less aggressive use of neuroleptics to treat mania are discussed. |
| Databáze: | OpenAIRE |
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