Ultrasound-assisted and trisodium citrate dihydrate-catalyzed green protocol for efficient and one-pot synthesis of substituted chromeno[3′,4′:5,6]pyrano[2,3-d]pyrimidines at ambient conditions
| Autor: | Khondekar Nurjamal, Goutam Brahmachari |
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| Rok vydání: | 2019 |
| Předmět: |
Reaction conditions
Barbituric acid 010405 organic chemistry Thiobarbituric acid Organic Chemistry One-pot synthesis Aqueous ethanol 010402 general chemistry Ultrasound assisted 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry TRISODIUM CITRATE DIHYDRATE Drug Discovery |
| Zdroj: | Tetrahedron Letters. 60:1904-1908 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2019.06.028 |
| Popis: | A simple, straightforward, and highly efficient multicomponent one-pot synthesis of a series of pharmaceutically interesting functionalized chromeno[3′,4′:5,6]pyrano[2,3-d]pyrimidines has been developed based on a low-cost and environmentally benign trisodium citrate dihydrate catalyst via ultrasound-assisted tandem reactions of 4-hydroxycoumarin, aromatic aldehydes, and barbituric acid/thiobarbituric acid in aqueous ethanol at ambient conditions. Metal-free synthesis, high atom-economy, good to excellent yields, short reaction time, operational simplicity, eco-friendliness, and mild reaction conditions are some of the important features of his protocol. |
| Databáze: | OpenAIRE |
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