Amphiphilic Copolymers having Saturated and Unsaturated Aliphatic Side Chains as Nano Carriers for Drug Delivery Applications

Autor:	Arthur C. Watterson, Virinder S. Parmar, Vijayendra Kumar, Bhavna Gupta, Najam A. Shakil, Ashish Dhawan, Abdullah Aman Khan, Jayant Kumar, Gaurav Kumar
Rok vydání:	2011
Předmět:	Degree of unsaturation Materials science Polymers and Plastics General Chemistry Combinatorial chemistry chemistry.chemical_compound chemistry Amide Polymer chemistry Drug delivery Amphiphile Materials Chemistry Ceramics and Composites Copolymer Side chain Nanocarriers Drug carrier
Zdroj:	Journal of Macromolecular Science, Part A. 48:1009-1015
ISSN:	1520-5738 1060-1325
DOI:	10.1080/10601325.2011.620427
Popis:	Nano-particles with controllable particle size and shape are of great interest in biomedical applications (1). From the standpoint of drug carrier design with wide applicability to a variety of hydrophobic drugs, an effective strategy would be to prepare a simple copolymer having the property to form stable polymeric micelles which can entrap hydrophobic drugs in the core (2). In this study, we have attached saturated and unsaturated long chain acid chlorides to the copolymer of PEG and dimethyl-5-aminoisophthalate via an amide linkage in order to make the copolymers amphiphilic. Further, bioactive compounds like β-carotene, which has considerable double bond unsaturation and curcumin, which has considerable aromatic unsaturation, were encapsulated in these amphiphilic copolymers which successfully demonstrated their drug loading ability.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c758abc9f2ce6f62ce99da160d57e01c https://doi.org/10.1080/10601325.2011.620427 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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