Novel tryptophan dioxygenase inhibitors and combined tryptophan dioxygenase/5-HT reuptake inhibitors
| Autor: | R. Hazelwood, D. J. Madge, M. Salter, H. T. Jones, R. Iyer |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Tryptamine
Chemistry 5 ht reuptake Organic Chemistry Clinical Biochemistry Tryptophan Pharmaceutical Science Metabolism Pharmacology Inhibitory postsynaptic potential Biochemistry Reuptake chemistry.chemical_compound Cerebrospinal fluid Dioxygenase Drug Discovery Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:857-860 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/0960-894x(96)00124-2 |
| Popis: | Tryptophan dioxygenase (TDO) is a liver enzyme that is responsible for the majority of the metabolism of tryptophan. A series of novel 3-(2-pyridylethenyl)indoles are shown to be potent inhibitors of TDO with selected members of the series also having 5-hydroxy tryptamine (5-HT) reuptake inhibitory activity. These compounds are shown to provide significant increases in the levels of tryptophan and 5-HT in the cerebrospinal fluid and are thus of interest for antidepressant therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect