Exposure to levonorgestrel increases nest acquisition success and decreases sperm motility in the male fathead minnow (Pimephales promelas)
| Autor: | Jack S. Frankel, Tyler Frankel, Lance T. Yonkos, Franklin R. Ampy |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system biology Reproductive success Health Toxicology and Mutagenesis Semen 010501 environmental sciences Minnow Fecundity 01 natural sciences Sperm Andrology 03 medical and health sciences 030104 developmental biology biology.animal medicine Environmental Chemistry Levonorgestrel Pimephales promelas Sperm motility 0105 earth and related environmental sciences medicine.drug |
| Zdroj: | Environmental Toxicology and Chemistry. 37:1131-1137 |
| ISSN: | 0730-7268 |
| Popis: | Progestins are utilized as a component of human contraceptives, and commonly enter the environment via wastewater treatment plant effluent. Certain progestins activate fish androgen receptors and cause decreases in fecundity and masculinization of females. We used a nest acquisition assay and computer-assisted sperm analysis to examine the effects of levonorgestrel on male fathead minnow (Pimephales promelas) reproductive fitness. Males were exposed to 0, 10, or 100 ng/L levonorgestrel for 14 d. Combinations of a control male and a male from one of the treatments were placed into a competitive nesting assay, and the time each male spent holding the nest and time spent exhibiting aggressive behaviors were analyzed at 48 h postexposure. Semen samples were analyzed for total motility, straight-line velocity, curvilinear velocity, average path velocity, linearity, beat cross frequency, and wobble at 0, 30, 60, 90, and 120 s postactivation. Males exposed to either 10 or 100 ng/L of levonorgestrel exhibited increased nest acquisition success and lower levels of aggression compared with control-control pairings, as well as decreases in multiple sperm motion characteristics. Our results suggest that further research is required to ascertain the effects of levonorgestrel on male gamete quality and reproductive behaviors. Environ Toxicol Chem 2018;37:1131-1137. © 2017 SETAC. |
| Databáze: | OpenAIRE |
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