Autor:	Diana Alexieva, Yi Long, Rupa Sarkar, Hansraj Dhayan, Emmanuel Bruet, Robert Winston, Igor Vorechovsky, Leandro Castellano, Nick Dibb
Rok vydání:	2020
Popis:	We report that low level background splicing by normal genes can be used to predict the likely effect of splicing mutations upon cryptic splice site activation and exon skipping, with emphasis on the DBASS databases, BRCA1, BRCA2 and DMD. In addition we show that background RNA splice sites are also involved in pseudoexon formation, recursive splicing and aberrant splicing in cancer. We discuss how background splicing information might inform splicing therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c73d120b4533cfa8dd4fbd7b2e2836d6 https://doi.org/10.21203/rs.3.rs-92665/v1 Zobrazit plný text záznamu