Friend or foe?
Autor: | Vittorio Colantuoni, Pamela Ziccardi, Gianluigi Mazzoccoli, Valeria Rosato, Giovanna D'Agostino, Giovanna Polcaro, Tommaso Colangelo, Angelo Lupo, Livio Muccillo, Lina Sabatino |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Cancer Research Tumor microenvironment Stromal cell Colorectal cancer Mesenchymal stem cell Cancer Biology Bioinformatics medicine.disease Transcriptome 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Oncology 030220 oncology & carcinogenesis Genetics Cancer research medicine Cancer-Associated Fibroblasts sense organs |
Zdroj: | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1867:1-18 |
ISSN: | 0304-419X |
DOI: | 10.1016/j.bbcan.2016.11.001 |
Popis: | The network of bidirectional homotypic and heterotypic interactions established among parenchymal tumour cells and surrounding mesenchymal stromal cells generates the tumour microenvironment (TME). These intricate crosstalks elicit both beneficial and adverse effects on tumour initiation and progression unbalancing the signals and responses from the neighbouring cells. Here, we highlight the structure, activities and evolution of TME cells considering a novel colorectal cancer (CRC) classification based on differential stromal composition and gene expression profiles. In this scenario, we scrutinise the molecular pathways that either change or become corrupted during CRC development and their relative prognostic value. Finally, we survey the therapeutic molecules directed against TME components currently available in clinical trials as well as those with stronger potential in preclinical studies. Elucidation of dynamic variations in the CRC TME cell composition and their relative contribution could provide novel diagnostic or prognostic biomarkers and allow more personalised therapeutic strategies. |
Databáze: | OpenAIRE |
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