Automated radiochemical synthesis and biodistribution of [11C]l-α-acetylmethadol ([11C]LAAM)

Autor:	Evan D. Kharasch, Kiran Kumar Solingapuram Sai, Patrick Zerkel, Zhude Tu, Jinda Fan, Robert H. Mach
Rok vydání:	2014
Předmět:	Biodistribution Acetylmethadol chemistry.chemical_compound Radiation Opioid chemistry Pet ligand medicine Specific activity Tissue distribution Pharmacology Methadone medicine.drug
Zdroj:	Applied Radiation and Isotopes. 91:135-140
ISSN:	0969-8043
Popis:	Long-acting opioid agonists methadone and l-α-acetylmethadol (LAAM) prevent withdrawal in opioid-dependent persons. Attempts to synthesize [11C]-methadone for PET evaluation of brain disposition were unsuccessful. Owing, however, to structural and pharmacologic similarities, we aimed to develop [11C]LAAM as a PET ligand to probe the brain exposure of long-lasting opioids in humans. This manuscript describes [11C]LAAM synthesis and its biodistribution in mice. The radiochemical synthetic strategy afforded high radiochemical yield, purity and specific activity, thereby making the synthesis adaptable to automated modules.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c72ca5224b85daa38d22ed7b55412104 https://doi.org/10.1016/j.apradiso.2014.05.019 Zobrazit plný text záznamu Full Text from ScienceDirect