Study of a 1,8-naphtylimide derivative as uridine diphosphate selective probe: Synthesis, optical properties and in vivo imaging application
| Autor: | Xue Wei Lv, Xiao Guang Xie, Ying Zhou, Guang Ke Wang, Xiao Ju Zou |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Fluorescence-lifetime imaging microscopy biology 010405 organic chemistry Stereochemistry Process Chemistry and Technology General Chemical Engineering 010402 general chemistry Ligand (biochemistry) biology.organism_classification 01 natural sciences Fluorescence 0104 chemical sciences carbohydrates (lipids) HeLa Uridine diphosphate chemistry.chemical_compound chemistry Biophysics Moiety Nucleotide Preclinical imaging |
| Zdroj: | Dyes and Pigments. 142:552-557 |
| ISSN: | 0143-7208 |
| Popis: | A 1, 8-naphtylimide-based probe 1 was developed for fluorescence sensing of uridine diphosphate (UDP). Probe 1 selectively recognized UDP in solvant system (DMSO-H 2 O) over other structurally similar nucleotides. Among all the tested targets, only the addition of UDP resulted in fluorescence enhancement of about 13-fold. Probe 1 , the first receptor moiety without metal center, could recognize UDP only by multi H-bonds formed between the organic ligand and the base group in nucleotide. Moreover, probe 1 exhibited excellent cell permeability. The fluorescence imaging of UDP by probe 1 in Hela cells and Caenorhabditis elegans ( C. elegans ) demonstrated its potential as a fluorescent sensor for in vivo imaging of UDP. |
| Databáze: | OpenAIRE |
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