Effect of picrotoxin and bicuculline on desensitization of the GABA receptor/Cl− ionophore complex
| Autor: | Shukalova Tf, N. P. Belykh, I. G. Rebrov, Kryzhanovskiĭ Gn, R. N. Glebov |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_treatment
Ionophore General Medicine Convulsants Pharmacology Bicuculline General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound GABA receptor complex nervous system chemistry GABA receptor Anesthesia medicine Picrotoxin medicine.drug Desensitization (medicine) |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 118:852-855 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02444447 |
| Popis: | A study is performed of the effect of the convulsants picrotoxin and bicuculline, blockers of GABA-dependent Cl−-conductivity, on the rate of desensitization of muscimol-induced36Cl− entry into synaptoneurosomes isolated from rat cortex. Both picrotoxin and bicuculline, despite the difference in the mechanisms of inhibition of the GABA receptor/Cl− ionophore complex, markedly reduce the rate of desensitization. However, the initial moment of the action of both convulsants is characterized by inhibition of Cl− transport alone, without a drop of the rate of desensitization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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