Assessment of trabecular bone strength at in vivo CT imaging with space-variant hysteresis and finite element modelling
| Autor: | Anneliese D. Heiner, Cheng Chen, Punam K. Saha, Ryan Amelon |
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| Rok vydání: | 2016 |
| Předmět: |
Reproducibility
medicine.medical_specialty Materials science Correlation coefficient Bone disease Osteoporosis Modulus 02 engineering and technology medicine.disease Finite element method 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine 0202 electrical engineering electronic engineering information engineering medicine 020201 artificial intelligence & image processing Radiology Cadaveric spasm Image resolution Biomedical engineering |
| Zdroj: | ISBI |
| Popis: | Osteoporosis is a common bone disease associated with reduced bone strength and increased fracture risk. Finite element modelling (FEM) is a powerful tool to assess bone strength. Fast acquisition and highly reduced radiation in latest multi-row detector CT (MDCT) put it as a frontline imaging modality to assess in vivo trabecular bone (TB) microarchitecture and strength. In current CT image resolution, conventional segmentation methods fail to maintain TB network connectivity limiting reliable assessment of TB strength using FEM. In this paper, we present a new space-variant hysteresis approach to maintain TB connectivity while preserving marrow pores and a high quality mesh generator for FEM. We examine the effectiveness in estimating TB strength. The reproducibility and the ability to predict actual bone strength were examined on MDCT images of cadaveric ankle specimens under in vivo conditions. An intra-class correlation coefficient of 0.97 was observed in computed Young's modulus from repeat scans, and a high linear correlation (R2=0.92) were found between computed and experimental Young's modulus. |
| Databáze: | OpenAIRE |
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