Knocheninduktion mit 'Bone morphogenetic protein' (BMP)

Autor:	B.-D. Katthagen
Rok vydání:	2008
Předmět:	Bone morphogenetic protein 7 Bone morphogenetic protein 6 Bone morphogenetic protein 5 Chemistry Bone morphogenetic protein 8A Bone morphogenetic protein 10 Orthopedics and Sports Medicine Surgery Bone regeneration Bone morphogenetic protein Bone morphogenetic protein 2 Cell biology
Zdroj:	Zeitschrift für Orthopädie und ihre Grenzgebiete. 125:559-566
ISSN:	1438-941X 0044-3220
DOI:	10.1055/s-2008-1044755
Popis:	32 experiments in 22 rabbits were performed to investigate the bone regeneration after implantation of lone morphogenetic protein (BMP) in a 6 mm drill-hole of the distal femoral condyle. Two different BMP products have been used. A bone regeneration is to be observed partially at the surface of BMP, but in comparison to the control defects quantitatively insignificant. There is a significant difference in comparison to the bone substitutes Collapat and Pyrost, which proved well (highly significant more bone regeneration) in the same experimental set up. The biology of bone regeneration by; 1. osteogenic transplantation; 2. osteoinduction and 3. osteoconduction ist discussed in detail. According to the own experiments the principle of osteoinduction with BMP is not yet useful for general clinical practice. Probably the osteoinductive effect is disturbed by immunological processes. The extraction of pure "osteogenin" from BMP seems to be important.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c721123981846dc8682e643045c28d3d https://doi.org/10.1055/s-2008-1044755 Zobrazit plný text záznamu