Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats

Autor:	Yu. V. Rumyantseva, A. V. Panov, V. S. Tyukova, I. N. Senchikhin, D. I. Mendeleev, E. S. Zhavoronok, S. A. Kedik, A. Zh. Fursova, N. G. Kolosova
Rok vydání:	2020
Předmět:	Pharmacology 010405 organic chemistry Chemistry Infrared spectroscopy 01 natural sciences 0104 chemical sciences Solvent Thermogravimetry 010404 medicinal & biomolecular chemistry Differential scanning calorimetry Drug Discovery Disulfiram medicine Thermal stability Inclusion (mineral) Hydroxypropyl β cyclodextrin Nuclear chemistry medicine.drug
Zdroj:	Pharmaceutical Chemistry Journal. 53:1158-1163
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-020-02140-y
Popis:	Formation of inclusion complexes from disulfiram and hydroxypropyl-β-cyclodextrin was confirmed using x-ray diffraction, differential scanning calorimetry, and thermogravimetry followed by IR spectroscopy of the evolved gas mixture. Inclusion complexes were prepared in two ways using EtOH or distilled H2O as the solvent. Formation of an inclusion complex increased the thermal stability of disulfiram. Biological studies showed that the disulfiram inclusion complex was effective for preventing cataracts in OXYS rats.
Databáze:	OpenAIRE
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