Surgical clips vs. iodine-125 (125I) seeds for marking the location of nonpalpable malignant breast lesions: preliminary results
| Autor: | A.D. González Jiménez, S. Martínez Meca, A.C. Rebollo Aguirre, I. Mendoza Arnau, R. Sánchez Sánchez, M. Culiañez Casas |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Ultrasound medicine.disease Stain Group B 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences 0302 clinical medicine Breast cancer 030220 oncology & carcinogenesis medicine General Earth and Planetary Sciences Mammography Radiology CLIPS medicine.symptom business computer General Environmental Science Gamma probe computer.programming_language |
| Zdroj: | Radiología (English Edition). 62:38-45 |
| ISSN: | 2173-5107 |
| Popis: | Objectives To assess the usefulness of iodine-125 (125I) seeds as an alternative to surgical clips for marking the location of nonpalpable malignant breast lesions for surgery. Material and methods We included patients with histologically confirmed nonpalpable malignant lesions treated by surgery in 2015 or 2016. Patients were randomly assigned to presurgical marking with metallic clips (Group A) or with 125I seeds (Group B). In both groups, marking was guided by ultrasound and/or mammography depending on the radiologic characteristics of the lesion. During surgery, a gamma probe was used and afterward the presence of seeds in the surgical specimen was checked radiologically. In the histological analysis, the absence of tumour in the stain was considered free margins. We analysed the following variables: age, lesion characteristics (laterality, mean size on MRI and in the surgical specimen, radiological type), and presence/absence of free margins. Results In Group A (n = 53), the most common histologic subtypes were infiltrating ductal carcinoma (IDC, 84.9%) and luminal A (LA, 49.1%); the mean size of the lesions was 1.8 cm. In Group B (n = 45), the most common histologic subtypes were IDC (82.2%) and LA (46.5%); the mean size of the lesions was 1.5 cm. In Group A, 13.2% had involved margins and 13.2% underwent a second surgical intervention. In Group, B 11.4% had involved margins and 7.5% underwent a second surgical intervention. The differences between groups were not significant (p = 0.7 for involved margins and p = 0.5 for reintervention). The volume of the surgical specimens was significantly lower in Group B than in Group A (128.68 cm3 vs. 189.37 cm3; p Conclusions Using 125I seeds was feasible and enabled significantly smaller surgical specimens than using metallic clips. |
| Databáze: | OpenAIRE |
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