Technetium coordination ability of cysteine-containing peptides: X-ray absorption spectroscopy of a 99Tc labelled endothelin derivative

Autor:	Ludger Dinkelborg, Bernhard Noll, Christoph Stephan Hilger, Hartmut Spies, H. Nitsche, T. Reich, W. Semmler, R. Jankowsky, Bernd Johannsen
Rok vydání:	1997
Předmět:	chemistry.chemical_classification X-ray absorption spectroscopy animal structures Radiation integumentary system Absorption spectroscopy Stereochemistry Chemistry Sequence (biology) Peptide Antiparallel (biochemistry) chemistry.chemical_compound Atom Derivative (chemistry) Cysteine
Zdroj:	Applied Radiation and Isotopes. 48:1045-1050
ISSN:	0969-8043
Popis:	The coordination mode of a 99 Tc-labelled endothelin derivative, Asp-Gly-Gly-Cys-Gly-Cys-Phe-(D-Trp)-Leu-Asp-Ile-Ile-Trp, in solution was determined by X-ray absorption spectroscopy (XAS). XAS analysis revealed that coordination of the [TcO] 3+ core is restricted to the sequence -Cys-Gly-Cys-. The preferred coordination by the cysteinyl thiol group prevents involvement of any donor atom other than sulphur, thus forming purely S -coordinate 1:2 complexes. Two occurring 99 Tc complex species with identical coordination spheres were identified and seem likely to represent parallel and antiparallel peptide chain orientation isomers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c702e40517c273afb802a12dc33659fa https://doi.org/10.1016/s0969-8043(97)00115-2 Zobrazit plný text záznamu Full Text from ScienceDirect