| Autor: |
Edward T. Krementz, J. H. Muchmor, William J. George, R. D. Carter, Janet E. Preslan |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy ISBN: 9782817807843 |
| DOI: |
10.1007/978-2-8178-0782-9_58 |
| Popis: |
High-dose intra-arterial chemotherapy with concomitant hemofiltration (HICCH) has potential usefulness in the pre-operative or perioperative setting of treating patients with advanced intra-abdominal or intra-thoracic malignancies. Using high-dose intra-arterial chemotherapy together with concomitant hemofiltration, the effluent blood from a tumor-bearing region can be rapidly cleared of the peak chemotherapeutic drug level. This allows then the delivery of higher drug doses to a regionally confined malignancy. The use of this type of system was originally defined by Dedrick et al [1] for the treatment of patients with primary brain tumors. Aigner et al and Muchmore et al have investigated similar systems for patients with advanced intra-abdominal malignancies [2, 3]. In a group of 25 patients with advanced intra-abdominal and intra-thoracic malignancies, some have successfully undergone 40 treatments with high-dose regional chemotherapy plus concomitant hemofiltration at the Tulane Medical Center Hospital. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
