pH- and temperature-induced release of doxorubicin from multilayers of poly(2-isopropyl-2-oxazoline) and tannic acid
| Autor: | Meltem Haktaniyan, Suleyman Atilla, Eda Cagli, Irem Erel-Goktepe |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Polymers and Plastics Protonation macromolecular substances 02 engineering and technology Oxazoline 010402 general chemistry 01 natural sciences Lower critical solution temperature chemistry.chemical_compound Tannic acid polycyclic compounds Materials Chemistry medicine Molecule Organic chemistry Doxorubicin organic chemicals Organic Chemistry Layer by layer technology industry and agriculture 021001 nanoscience & nanotechnology 0104 chemical sciences carbohydrates (lipids) chemistry 0210 nano-technology Isopropyl medicine.drug Nuclear chemistry |
| Zdroj: | Polymer International. 66:1851-1863 |
| ISSN: | 0959-8103 |
| Popis: | We present a simple strategy to prepare Doxorubicin (DOX) containing hydrogen-bonded films of poly(2-isopropyl-2-oxazoline) (PIPOX) and Tannic Acid (TA) which release DOX at acidic conditions, while release minimal amount of DOX at physiological pH. Water soluble complexes of TA and DOX (TA-DOX) were prepared prior to film construction. PIPOX and TA-DOX were deposited at the surface at pH 6.5 using LbL technique. We found that multilayers released minimal amount of DOX at physiological pH due to further ionization of TA with increasing pH and enhanced electrostatic interactions among TA and DOX. In contrast, pH-induced release of DOX was observed at moderately acidic conditions due to protonation of TA as the acidity increased and loss of electrostatic interactions among TA and DOX. Moreover, we found that raising the temperature from 25 °C to 37.5 °C increased the amount of DOX released from the surface. This can be rationalized with the conformational changes within the multilayers correlated with the lower critical solution temperature (LCST) behaviour of PIPOX and increased kinetic energy of DOX molecules. Considering the acidic nature of tumor tissues and important biological properties of PIPOX and TA, these multilayers are promising for pH- and temperature-triggered release of DOX from surfaces. |
| Databáze: | OpenAIRE |
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