Parallel Plate Flow Chamber Device for Evaluation of Cell Retention of Electrospun Zein Fiber Film Under Steady Shear
| Autor: | Zhang Yue, Naian Shen, Jin-Ye Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Multidisciplinary
Materials science Parallel-plate flow chamber 02 engineering and technology Adhesion 030204 cardiovascular system & hematology 021001 nanoscience & nanotechnology Electrospinning 03 medical and health sciences 0302 clinical medicine Monolayer Nano Shear stress Fiber Composite material 0210 nano-technology Cell adhesion |
| Zdroj: | Journal of Shanghai Jiaotong University (Science). 26:69-75 |
| ISSN: | 1995-8188 1007-1172 |
| Popis: | Shear stress environment is an important factor in the study of vascular tissue engineering. It is a key issue to improve the adhesion ability of endothelial cells in shear stress environment to format a complete monolayer of endothelial cells on the inner surface of the artificial blood vessel. This study uses electrospinning technology to construct a zein film with nano structure to provide basement membrane for cell retention study. Two parallel plate flow chamber devices are designed to simulate the fluid environment of the blood vessel to compare the adhesion ability of EA.hy926 and L929 cells on the fiber film under shear stress. From the data of cell retention, we find that the shear stress in each hole of 6-hole device is much uniform than that of 18-hole device. This optimized 6-hole device can be used to compare the anti-detaching ability of cells between various surfaces. |
| Databáze: | OpenAIRE |
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