The CD69 early activation molecule is overexpressed in human bone marrow mast cells from adults with indolent systemic mast cell disease
| Autor: | Alberto Orfao, Luz Del Castillo, Luis Escribano, Alberto Cantalapiedra, Antonio Torrelo, Sonia Herrero, Raquel Navalón, Jesús Villarrubia, Jesús F. San Miguel, Pilar Bravo, Rosa Núñez, Lourdes Navarro, José L. Navarro, Beatriz Díaz-Agustín |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test CD69 Myelodysplastic syndromes hemic and immune systems chemical and pharmacologic phenomena Hematology Biology Mast cell medicine.disease Flow cytometry medicine.anatomical_structure Antigen immune system diseases Gene expression Immunology medicine Bone marrow Pathological |
| Zdroj: | British Journal of Haematology. 106:400-405 |
| ISSN: | 0007-1048 |
| DOI: | 10.1046/j.1365-2141.1999.01572.x |
| Popis: | We have analysed the quantitative expression of surface CD69 antigen on human mast cells (MC), from both normal and pathological bone marrow (BM) samples, using flow cytometry. Our major aim was to analyse whether CD69 is constitutively expressed by normal BMMC and to explore the possible differences between CD69 expression by BMMC from normal controls and patients suffering from different pathological conditions. The constitutive expression of surface CD69 was clearly demonstrated in BMMC; however, systemic mast cell disease (SMCD) patients showed significantly higher levels of surface CD69 expression than healthy controls (P 0.05). From the other groups of patients, monoclonal gammopathy of unknown significance (P = 0.04), myelodysplastic syndromes (P = 0.03) and paediatric mastocytosis (P = 0.003) cases showed a significantly higher expression of surface CD69 as compared to normal subjects. In summary, our findings show that the CD69 antigen is overexpressed in SMCD patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text