An Epidemiological Study of Penicillin-Resistant Streptococcus pneumoniae in Japan

Autor: Shigeru YOSHIDA, Mamiko INOUE, Yoshinori SHIMIZU, Koji AKIZAWA, Nobuyuki UEHARA, Syunji TAKAHASHI, Kozo FUJITA, Yoshihiko SAITO, Tyoitiro TAKAHASHI, Satoshi IWATA, Takashi NOTOYA, Teiko TOMIYA, Yoshitake SATO, Yoshihei KAWASHIMA, Hiromi HASEGAWA, Yoko SUZUKI, Hidenori MEGURO, Hideyuki MARUYAMA, Kimiko UBUKATA, Mutumi SUGIURA, Namie NISHIBE, Takashi TANAKA, Sayoko KAWAKAMI, Kihachiro SHIMIZU, Keisuke SUNAKAWA, Satoshi KOSAKA, Noriyuki SATO, Yoshio KOBAYASHI, Hiroshi UCHIDA, Ken KIKUCHI, Takashi INAMATSU, Tsutomu HATAKEYAMA, Katsuko OKUZUMI, Toyoko OGURI, Tsuyoshi TAJIMA, Koichi WADA, Misao TAKANO, Kyoko OZAKI, Yoshio DAIMON, Yasunobu NISHIYAMA, Seishi ASARI, Kazuko TAHARA, Yoshiro MORIKAWA, Kanji MIKI, Minoru MURASE, Masahumi NUKINA, Hideyuki ITAHA, Emi SASAKI, Ryokan FUJIKAMI, Mutsumi NAGATOMI, Shigeru ONARI, Seiya KASHIYAMA, Yoshinori KUROKAWA, Seiko KUNIHIRO, Kiyoshi NEGAYAMA, Mitsuharu MURASE, Hitoshi MIYAMOTO, Koichi TAKEMORI, Takashi MOTOHIRO, Yasutaka SAKATA, Mikinori TSUMURA, Takashi YAMADA, Shuji YAMADA, Kazuyuki SUGAWARA
Rok vydání: 1994
Předmět:
Zdroj: Journal of the Japanese Association for Infectious Diseases. 68:1338-1351
ISSN: 1884-569X
0387-5911
DOI: 10.11150/kansenshogakuzasshi1970.68.1338
Popis: In order to investigate penicillin resistance (Pcr) in Streptococcus pneumoniae from clinical sources in Japan, a total 1,127 strains of S. pneumoniae was collected at random from 36 institutions participating to "Working group for Pcr S. pneumoniae" around the country in 1993-1994. These strains were isolated more frequently from sputum (38.2%), throat (31.4%), nasal discharge (16.4%), and otorrhea (5.7%). A small number of isolates from blood (19 strains; 1.8%), cerebrospinal fluid (11 strains; 1.0%), and pleural fluid (2 strains; 0.2%) were included respectively. Patients from whom S. pneumoniae was isolated have mostly been associated with children or = 0.125 micrograms/ml for penicillin G were defined as a Pc resistance. Of the 1,127 strains, 471 strains (41.8%) were identified as a Pc resistance. Pcr S. pneumoniae were almost resistant to other beta-lactams, including ampicillin, oxacillin, ceftizoxime, cefixime, cefdinir. Although, the MICs of imipenem and panipenem ragned from 0.004-2.0 micrograms/ml with 2 peaks distributions, these antibiotics inhibited the growth of most of Pcr S. pneumoniae at the lowest concentrations of < or = 0.5 microgram/ml. Only vancomycin resistant strain was not detected in these isolates. Most of the Pcr strains were simultaneously resistant to macrolides and minocycline. Further more, isolation frequencies of Pcr S. pneumoniae in west Japan, were relatively high compared with those of east Japan.
Databáze: OpenAIRE
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