Tissue Distribution of Astaxanthin Formulation in Rats
| Autor: | G.K. Surindar Singh, N.A.A. Zulkefli, Meor Mohd Redzuan Meor Mohd Affandi, M.A. Ismail |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Nano size
Nutrition and Dietetics Chromatography Materials science Public Health Environmental and Occupational Health Negative control 04 agricultural and veterinary sciences 040401 food science Bioavailability chemistry.chemical_compound 0404 agricultural biotechnology chemistry Globule size Astaxanthin Emulsion Distribution (pharmacology) Tissue distribution Food Science |
| Zdroj: | Current Nutrition & Food Science. 14:329-334 |
| ISSN: | 1573-4013 |
| DOI: | 10.2174/1573401313666170614092146 |
| Popis: | Background: Nano size emulsion of Astaxanthin has been successfully developed. However, its bioavailability enhancement benefit in form of concentration absorbed and tissue distribution has not been studied yet. Objective: This study investigated the relationship between globule size and tissue distribution of different types of astaxanthin formulation namely macro, nano and oil solution. Method: Twenty male rats were divided into four groups and orally fed with the formulations for seven days. The first, second, and third group of rats were fed with nano emulsion, macro emulsion and oil solution, respectively. The final group was used as negative control. The lungs, spleen, kidney, heart and liver were isolated for distribution study. Results: It was found that the nano size emulsion of astaxanthin contained the highest distribution in all organs while the highest concentration of astaxanthin was found in the spleen for each type of formulation. Conclusion: it is concluded that nano sized emulsion improved distribution and enhance the bioavailability of astaxanthin. |
| Databáze: | OpenAIRE |
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