The Pemoline Model of Self-Injurious Behavior: An Update
| Autor: | Darragh P. Devine |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Emotional lability Cognition medicine.disease 03 medical and health sciences 0302 clinical medicine Animal model Neurochemical Pemoline medicine Autism Patient group medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery 030304 developmental biology medicine.drug |
| Zdroj: | Methods in Molecular Biology ISBN: 9781493995530 |
| DOI: | 10.1007/978-1-4939-9554-7_6 |
| Popis: | Neurodevelopmental disorders typically comprise a complex constellation of behavioral symptoms and neurochemical abnormalities. However, many of the symptoms are inconsistently expressed within any one particular patient group or overlap between patient groups. In other words, there is usually heterogeneity of symptoms between diagnostic groups, and there is often partial homogeneity of symptoms across these groups. These include cognitive deficits, emotional lability, and perseverative or aberrant behaviors. Animal models of neurodevelopmental disorders typically reproduce or mimic specific genetic, neurochemical, and/or behavioral sequelae, although they typically fail to replicate the entire spectrum of biological and behavioral characteristics. Indeed, it may be impractical or even impossible to model the entire spectrum of characteristics of a disorder in any single animal model. A focus on one or more specific behavioral characteristics that occur in multiple neurodevelopmental disorders (e.g., self-injury) may be a fruitful strategy. The development of these behaviorally focused models may yield increased understanding of the endogenous and environmental factors that confer vulnerability for aberrant behaviors that commonly occur in these disorders. One such behaviorally focused animal model is the pemoline model of self-injurious behavior. |
| Databáze: | OpenAIRE |
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