Oestradiol regulated keratin gene expression in rat vaginal epithelial cells
| Autor: | P. D. Gupta, K. Sridhar Rao, Alla G. Reddy |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Regulation of gene expression
chemistry.chemical_classification General Medicine Biology Molecular biology General Biochemistry Genetics and Molecular Biology chemistry Mitogen-activated protein kinase Gene expression Keratin biology.protein Inducer General Agricultural and Biological Sciences Gene hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Journal of Biosciences. 22:273-285 |
| ISSN: | 0973-7138 0250-5991 |
| Popis: | Oestradiol acts both as a mitogen and as an inducer of differentiation of target cells. The cellular responses to oestradiol are generally mediated through the regulation of gene expression, although nongenomic modes of action are also documented. The present observations show that the regulation of keratin gene expression in rat vaginal epithelial cells is under the influence of oestradiol. It is observed that oestradiol regulates both the qualitative and quantitative expressions of keratin polypeptides in a time dependent and sequence specific manner. These regulatory effects are the result of modulations in transcriptional, post-transcriptional and translational processes of these genes, brought about by the hormone in vaginal epithelial cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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