| Autor: |
Elvina Almuradova, irem öner, Murat Ayhan, Emre Yekedüz, Esma Turkmen Bekmez, Devrim Cabuk, Ahmet Gulmez, miraç özen, Melike Ozcelik, elif şenocak taşçı, Murat Dincer, Turgut Kaçan, Özgecan Dülgar, Ozlem Ozdemir, Melek Karakurt Eryilmaz, Ozkan Alan, Hasan Cagri Yildirim, Ebru Cilbir, Berna Öksüzoğlu, Serdar Turhal, Tugba Basoglu, Nazan Demir, Naziye Ak, Yusuf Karakas, Mutlu Dogan, Deniz Tataroğlu Özyükseler, Ali Inal, Abdullah Sakin, çağlar ünal, Ilhan Hacibekiroglu, Gulhan Ipek Deniz, Perran Fulden Yumuk, Dilek Erdem, Mehmet Ali Nahit Sendur, Cihan Erol, Suayib Yalcin, nelihan doğan, Bulent Karabulut, Ercan Ozden, Abdilkerim Oyman, Ozlem Er, Semra Paydas, Derya Kivrak Salim, Asude Aksoy |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
PurposeNeoadjuvant chemotherapy(NACT) in gastroesophageal junction(GEJ) and gastric cancer(GC) was shown to improve survival in recent studies. We aimed to share our real-life experience of patients who received NACT in order to compare the efficacy and toxicity profile of different chemotherapy regimens in our country.Methods This retrospective multicenter study included locally advanced GC and GEJ cancer patients who received NACT, and had pathological response evaluation between 2007 and 2021. Relation between CT regimens and pathological evaluation were analyzed. Results A total of 728 patients from 45 oncology centers in Turkey were included. Median age at the time of diagnosis was 60 (range: 18-68). Most frequent NACT regimens used were FLOT (65%), DCF (18%) and ECF (8.1%), respectively. In the total study group pCR rate was 8.2%, R0 resection rate 88.5%, and D2 dissection rate was 66.8%. Rate of pCR and near-CR (26.4%), and R0 resection (92.6%) were higher in FLOT arm (p= 0.005 and ConclusionIn our real-life study, FLOT regimen has superior survival outcome despite worse toxicity profile. Clinicians should tailor treatment regimens according to patients’ multifactorial status and comorbidities for to obtain best outcomes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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