Features of sexual development, immune status and biochemical parameters in boys suffering from acne
| Autor: | Elena N. Pilnik, Alexander O. Pyatibrat, Denis V. Zaslavsky |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Pediatrician (St. Petersburg). 11:29-36 |
| ISSN: | 2587-6252 2079-7850 |
| Popis: | Among skin diseases in children and adolescents, the most common pathology is acne. The main pathogenetic link of acne in adolescents is hormonal imbalance. The effect on the sebaceous glands of high concentrations of dihydrotestosterone causes a change not only in the quantitative but also in the qualitative composition of the sebaceous secretion. The study is devoted to assessing the characteristics of sexual development, immune status and biochemical parameters in boys suffering from acne. Materials and methods. Materials and methods. A comparative analysis of the state of immunity, sexual development, biochemical parameters of 147 boys suffering from acne, and 142 healthy boys who do not suffer from acne. It was found that the immune status of boys suffering from acne was characterized by a decrease in cytotoxic lymphocytes. In the peripheral blood of these boys, serum interferon , tumor necrosis factor , interleukins 1, 2, 8 and 10, as well as small circulating immune complexes were significantly higher than in the boys of the control group. In boys suffering from acne, in the puberty period, the concentration of prolactin in 1314 years is significantly lower, and testosterone levels are significantly higher than in boys of the control group of the same age. At 1517 years of age, the concentration of luteinizing hormone in boys with acne is significantly lower, and testosterone is higher than in boys in the control group. Evaluation of the degree of formation of secondary sexual characteristics indicates that boys suffering from acne differed from their peers from the control group by a small advance in sexual development. Thus, boys suffering from acne, characterized by advanced and disharmonious puberty. |
| Databáze: | OpenAIRE |
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