ChemInform Abstract: Synthesis of Tetrahydroisoquinoline Antitumor Natural Products: Construction of Tricyclic Lactams Through Pictet-Spengler-Type Cyclization of N-Methyl-3-arylmethylpiperazine-2,5-dione with Ethyl Diethoxyacetate

Autor:	Naoki Saito, Masashi Yokoya, Osamu Kawachi
Rok vydání:	2009
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Chemistry Stereochemistry Tetrahydroisoquinoline Renieramycin G Yield (chemistry) Cribrostatin-4 Total synthesis General Medicine Tricyclic
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
Popis:	6-Hydroxymethyl-7,8,10-trimethoxy-2,6-dimethyl-3,6,11,11a-tetrahydro-2H-pyrazino[1,2-b]isoquinoline-1,4-dione (10) was prepared stereoselectively by Pictet-Spengler-type cyclization of the O,N-acetal of 3-arylmethylpiperazine-2,5-dione (8) in high yield. This procedure provides an efficient route for the total synthesis of renieramycin G and cribrostatin 4.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c6bc2beee1a7518af1f374e73ede7077 https://doi.org/10.1002/chin.200918159 Zobrazit plný text záznamu Plný text