| Autor: |
Richard M. Gilley, J A Meulbroek, Zina Moldoveanu, John H. Eldridge, T. R. Tice, Jay K. Staas |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Current Topics in Microbiology and Immunology ISBN: 9783642745317 |
| DOI: |
10.1007/978-3-642-74529-4_6 |
| Popis: |
The potential of biocompatible and biodegradable microspheres as a controlled release oral vaccine delivery system has been examined. Orally-administered 1-10 micron microspheres composed of poly (DL-lactide-co-glycolide) were specifically taken up into the Peyer's patch lymphoid tissue of the gut, where those greater than or equal to 5 micron remained for up to 35 days. Microspheres less than 5 micron disseminated within macrophages to the mesenteric lymph nodes and spleen. In contrast to soluble staphylococcal enterotoxin B toxoid, oral immunization with enterotoxoid in microspheres induced circulating toxin-specific antibodies and a concurrent secretory IgA anti-toxin response in saliva and gut fluid. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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