Synthesis and bronchospasmolytic effects of benzocyclobutenic and benzocyclenic compounds

Autor:	Philippe Geoffroy, Paul Caubère, Charles Advenier, M. A. Zouaoui, M Blanc, A. A. Aatif, A Mouaddib, Brigitte Jamart-Grégoire, MC Carré, J.-P. Gnassounou
Rok vydání:	1990
Předmět:	Pharmacology Bicyclic molecule medicine.drug_class Chemistry Organic Chemistry Biological activity General Medicine Adenosine In vitro Bronchodilator Drug Discovery medicine Organic chemistry Theophylline medicine.drug
Zdroj:	European Journal of Medicinal Chemistry. 25:441-447
ISSN:	0223-5234
DOI:	10.1016/0223-5234(90)90008-q
Popis:	Two series of new benzocyclobutenic and benzocyclenic compounds were synthesized and tested for bronchospasmolytic effects. Theophylline was used as reference. Compound 1b was found to be 12.6 to 15.8-fold more potent in vitro than theophylline and devoid of antagonistic effects towards adenosine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c6b59f27d26e212a624d7b54855a9412 https://doi.org/10.1016/0223-5234(90)90008-q Zobrazit plný text záznamu