Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil
| Autor: | Raquel Carvalho Montenegro, Joyce Kelly R. da Silva, Jamile S da Costa, Pablo Luis B. Figueiredo, Lucas Botelho Jerônimo, Rosa Helena Veras Mourão, William N. Setzer, Laine Celestino Pinto, José Guilherme S. Maia |
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| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
food.ingredient DPPH medicine.medical_treatment Plant Science Biology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Eugenia stipitata food Drug Discovery Myrcia medicine 030304 developmental biology Pharmacology 0303 health sciences Psidium Traditional medicine Myrtaceae General Medicine biology.organism_classification Eugenia patrisii Terpenoid 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry |
| Zdroj: | Natural Product Communications. 16:1934578X2199615 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x21996156 |
| Popis: | This work analyzed the chemical compositions and evaluated the antioxidant and cytotoxic activities of essential oils (EO) of Eugenia patrisii (Epat), Eugenia stipitata (Esti), Myrcia splendens (Mspl), Myrcia sylvatica (Msyl), Psidium guajava (Pgua), and Psidium guineense (Pgui-1 and Pgui-2) from the Brazilian Amazon. Sesquiterpenoids were found in high concentrations in the oils of E. patrisii and M. splendens, which were rich in E-caryophyllene (32.0% and 45.8%); E. stipitata and M. sylvatica, which displayed germacrene D (11.8%) and germacrene B (24.5%); and P. guajava that showed epi-β-bisabolol (16.1%) as the main compound. However, P. guineense samples (Pgui-1 and Pgui-2) were rich in monoterpenoids such as limonene (Pgui-1: 30.2%; Pgui-2 30.4%) and α-pinene (Pgui-1: 22.5%; Pgui-2: 17.7%). The samples showed a weak and moderate antioxidant activities in the DPPH assay, displaying inhibition rates from 11.5% to 38.6% (at 10 mg/mL). All samples were cytotoxic against human cancer cells by the MTT method. Epat oil showed higher activity against melanoma (SKMEL-19, IC505.8 µg/mL), gastric (AGP01, IC503.2 µg/mL), and colon (HCT116, IC506.7 µg/mL). Meanwhile, the samples Pgua and Pgui were more active against breast cancer cells (MCF7, IC5012.4 µg/mL and 11.6 µg/mL, respectively). |
| Databáze: | OpenAIRE |
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