Lipase-catalyzed enantioseparation of alcohols containing a tetrazole ring

Autor:	Jan Plenkiewicz, Edyta Łukowska-Chojnacka, Urszula Bernaś
Rok vydání:	2012
Předmět:	biology Chemistry Organic Chemistry Alkylation Ring (chemistry) Catalysis Inorganic Chemistry chemistry.chemical_compound Sodium borohydride Chloroacetone Methyl vinyl ketone biology.protein Organic chemistry Tetrazole Physical and Theoretical Chemistry Lipase
Zdroj:	Tetrahedron: Asymmetry. 23:136-143
ISSN:	0957-4166
Popis:	A simple chemoenzymatic method for the preparation of optically active (5-aryltetrazolyl-2)-4-butan-2-ol, (5-aryltetrazolyl-2)-propan-2-ol, and their acetates has been developed. The starting compounds (5-aryltetrazolyl-2)-4-butan-2-one and (5-aryltetrazolyl-2)-propan-2-one were obtained by a Michael-type addition of 5-aryl substituted tetrazoles to methyl vinyl ketone, and alkylation of 5-aryl substituted tetrazoles with chloroacetone, respectively. Their reduction with sodium borohydride afforded racemic mixtures of (5-aryltetrazolyl-2)-4-butan-2-oles and (5-aryltetrazolyl-2)-propan-2-oles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c6ae425d27d0c075b9cdbc011d28e814 https://doi.org/10.1016/j.tetasy.2012.01.015 Zobrazit plný text záznamu Full Text from ScienceDirect