| Autor: |
Sabine Guesewell, Onicio B. Leal-Neto, Pietro Vernazza, Hans-Ruedi Schmid, Stefan P Kuster, Carol Strahm, Dorette Meier Kleeb, Andrée Friedl, Eva Lemmenmaier, Lorenz Risch, Philip Alexander Rieder, Matthias Schlegel, Dagmar Schmid, Remus Rutz, Philipp Kohler, Reto Stocker, Markus Ruetti, Danelle Vuichard-Gysin, Ulrike Besold, Angela Brucher, Thomas Egger, Benedikt Wiggli, Christian R Kahlert, Marco Seneghini, Carsten Moeller, Allison McGeer |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
BackgroundThe burden of long-term symptoms (i.e. long-COVID) in patients after mild COVID-19 is debated. Within a cohort of healthcare workers (HCW), frequency and risk factors for symptoms compatible with long-COVID are assessed.MethodsParticipants answered baseline (August/September 2020) and weekly questionnaires on SARS-CoV-2 nasopharyngeal swab (NPS) results and acute disease symptoms. In January 2021, SARS-CoV-2 serology was performed; in March, symptoms compatible with long-COVID (including psychometric scores) were asked and compared between HCW with positive NPS, seropositive HCW without positive NPS (presumable a-/pauci-symptomatic infections), and negative controls. Also, the effect of time since diagnosis and quantitative anti-S was evaluated. Poisson regression was used to identify risk factors for symptom occurrence.ResultsOf 3’334 HCW (median 41 years; 80% female), 556 (17%) had a positive NPS and 228 (7%) were only seropositive. HCW with positive NPS more frequently reported ≥1 symptom compared to controls (73%vs.52%, pvs.6%, pvs.10%, p=0.004) were more common. Exhaustion/burnout was reported by 24% of negative controls. Many symptoms remained elevated in those diagnosed >6 months ago; anti-S titers correlated with high symptom scores. Acute viral symptoms in weekly questionnaires best predicted long-COVID symptoms. Physical activity at baseline was negatively associated with neurocognitive impairment and fatigue scores.ConclusionsSeropositive HCW without positive NPS are only mildly affected by long-COVID. Exhaustion/burnout is common, even in non-infected HCW. Physical activity might be protective against neurocognitive impairment/fatigue symptoms after COVID-19.summaryIn this prospective healthcare worker cohort, participants with SARS-CoV-2-positive nasopharyngeal swab were most likely to report long-COVID symptoms, whereas seropositive participants without positive swab were only mildly affected. Physical activity at baseline was negatively associated with neurocognitive impairment and fatigue. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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