TACI-Fc gene therapy improves autoimmune sialadenitis but not salivary gland function in non-obese diabetic mice
| Autor: | Gabor G. Illei, John A. Chiorini, Jelle L. Vosters, Nienke Roescher, PP Tak |
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| Rok vydání: | 2011 |
| Předmět: |
Saliva
biology Salivary gland Transmembrane activator and CAML interactor medicine.disease Submandibular gland Immunoglobulin D Sialadenitis medicine.anatomical_structure stomatognathic system Otorhinolaryngology Immunology medicine biology.protein Receptor B-cell activating factor General Dentistry |
| Zdroj: | Oral Diseases. 18:365-374 |
| ISSN: | 1354-523X |
| DOI: | 10.1111/j.1601-0825.2011.01885.x |
| Popis: | Objective Sjogren’s syndrome (SS) patients show aberrant expression of the B cell-related mediators B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in serum and salivary glands (SGs). We studied the biological effect of neutralizing these cytokines by local gene transfer of the common receptor transmembrane activator and CAML interactor (TACI) in an animal model of SS. |
| Databáze: | OpenAIRE |
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