Semiquantitative assessment of breath hydrogen testing
| Autor: | Peter R. Gibson, Udaya Kalubovila, Peter M. Irving, Jacqueline Susanne Barrett |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Malabsorption Hepatology business.industry Confounding Gastroenterology Area under the curve Fructose malabsorption medicine.disease Ulcerative colitis Lactulose chemistry.chemical_compound chemistry Internal medicine medicine Lactose Breath hydrogen testing business medicine.drug |
| Zdroj: | Journal of Gastroenterology and Hepatology. 28:1450-1456 |
| ISSN: | 0815-9319 |
| DOI: | 10.1111/jgh.12199 |
| Popis: | Background and Aim A major use of breath hydrogen testing is to assess absorptive capacity for sugars to assist dietary design for management of gut symptoms. Qualitative reporting takes no account of the vigor of hydrogen response and provides little insight into degrees of malabsorption. This study aimed to describe a semiquantitative reporting method and to compare results with those reported qualitatively. Methods In consecutive Caucasian patients with Crohn's disease (n = 87), ulcerative colitis (59), functional gastrointestinal disorders (FGID) (162), and healthy controls (76), area under the curve was calculated for lactulose (15 g). This was compared with that for lactose (50 g) and fructose (35 g). Degree of malabsorption was categorized into arbitrary groups. Results Semiquantitative results for ≥ 30% (designated “convincing”) malabsorption was most similar to those using a qualitative cutoff value of 20 ppm, but in 38% and 21% of patients, the classification of malabsorption (nil or clinically significant) changed for fructose and lactose, respectively. Using a cutoff of 10 ppm, 49% and 5% were classified differently. Crohn's disease had a higher prevalence (42%) of convincing fructose malabsorption than controls (24%) or patients with FGID (33%) (P |
| Databáze: | OpenAIRE |
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