| Autor: |
Dinesh K. S., Krishnendhu C., Geethu Balakrishnan, Swapna Chitra S., Santhi Krishna A. S., George M. J., Anita Patel |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Biomedicine. 42:325-332 |
| ISSN: |
0970-2067 |
| DOI: |
10.51248/.v42i2.972 |
| Popis: |
Introduction and Aim: The prevalence of autism spectrum disorder has risen in the last two decades. Disruption of homeostasis of several species and genus of bacteria in the gut termed as dysbiosis is having a pivotal role in ASD pathophysiology. Invariable correlations between the behavioral severities of ASD and dysbiosis management have been affirmed through various previous studies. Bifidobacterium make a significant species appraised well in microbial studies linked with ASD. A randomized controlled trial was conducted to assess the efficacy of Ayurveda therapies in improving Bifidobacterial abundance in Autism children. Methodology: The study took place at the VPSV Ayurveda College Kottakkal's outpatient and in-patient units where 60 children with Autism were randomized to two groups. The intervention prolonged 30 days in total, with three rounds of assessment: baseline (0th day), interim (30th day), and final (60thday). Both the test and control groups received conventional multidisciplinary therapies for 60 days and additionally, the test group was given Ayurveda poly-herbal formulations and food and lifestyle instructions for first 30 days. The result was made through GI severity index measurement and 16SrRNA sequencing. Results: After one month of intervention with poly herbal compounds of Ayurveda along with lifestyle guidelines and conventional therapies a statistically significant improvement observed in the relative abundance of Bifidobacterium in intervention group compared to control group. Conclusion: Poly herbal compounds of Vilwadi Gulika and Rajanyadi choornam along with the dietary lifestyle guidelines and multidisciplinary interventions has played a big role in improving Bifidobacteria in autistic children. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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