Synthesis and transformations of 1-methyl-4-azafluorene

Autor:	V. A. Rezakov, N. S. Prostakov, V. O. Fedorov, Aa Fomichev, P. K. Radzhan, Anatoly T. Soldatenkov
Rok vydání:	1982
Předmět:	chemistry.chemical_compound Chemistry Nitration Organic Chemistry Pyridine Organic chemistry Ring (chemistry) Medicinal chemistry Catalysis
Zdroj:	Chemistry of Heterocyclic Compounds. 18:390-394
ISSN:	1573-8353 0009-3122
DOI:	10.1007/bf00503560
Popis:	By means of catalytic dehydrocyclization of dimethyl-substituted 2-phenylpyridines in a pyridine ring to 1(2,3)methyl-4-azafluorenes with subsequent oxidation, synthesis of alkaloid onychine — 1-methyl-4-azafluorene — several of its isomers were achieved. Using 1-methyl-4-azafluorene, we obtained a C9 furfurylidene product, substituted tetrahydroindine[1,2-b]pyridine and NH-indine[1,2-b]-pyridine. We obtained 7-nitro-1-methyl-4azafluorene by nitration of onychine and oxidation of nitro-substituted azafluorene; this indicates an identical orientation of 4-azafluoren(one) and fluoren(one) during nitration.
Databáze:	OpenAIRE
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