Novel description of aldosterone synthase CYP11B2 -344 T>C gene polymorphism related to hypertension in Mexican Amerindians: Teenek, Mixtec and Mayans
| Autor: | Filogonio Lopez-Pacheco, Gilberto Vargas-Alarcón, José Manuel Rodríguez-Pérez, Antonio Arnaiz-Villena, José Manuel Fragoso, Julio Granados, David Cruz-Robles, Galileo Escobedo, Ester Muñiz, Julio Cesar Arriaga |
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| Rok vydání: | 2017 |
| Předmět: |
Aldosterone synthase
Genetics biology Population genetics 030204 cardiovascular system & hematology medicine.disease Obesity 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) biology.protein medicine 030212 general & internal medicine Gene polymorphism Metabolic syndrome Allele Genotyping |
| Zdroj: | International Journal of Modern Anthropology. 1:52 |
| ISSN: | 1737-8176 1737-7374 |
| Popis: | This is a report on population genetics of -344 T>C polymorphism in Amerindians for the first time. The aim was to establish the frequency of this polymorphism present in the 5’ promoter region of the CYP11B2 gene in Amerindian (Mayans, Mixtecos, and Teenek) and Mestizo populations from Mexico. It has been associated with an aldosterone increase and hypertension. Analyses were carried out by 5’ exonuclease TaqMan genotyping assays in a group of 608 unrelated individuals belonging to four different Mexican populations (301 Mexican Mestizos, 106 Mayans, 151 Mixtecos, and 50 Teenek). The frequencies in these populations were compared to those reported in other ethnic groups. Results showed significant highest frequencies of -344 T allele in Mexican populations (Mestizos and Amerindians) when compared to Europeans and Asians (p C polymorphism distinguishes the Mexican population form others, including Europeans and Asians. The knowledge of the distribution of this allele could be useful in Mexican Amerindians for hypertension prevention, epidemiology and anthropology. Keywords: Amerindians; Aldosterone; Renin; Angiotensin; Cytochrome P450; Mexican; Genetics; Teneek; Mixtec; Mayans; Hypertension; Obesity; Metabolic Syndrome; Diabetes |
| Databáze: | OpenAIRE |
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