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Ferric glycinate bioavailability and its absorption control by iron stores was assessed by radioisotopic studies in 30 subjects (17 women and 13 men), in apparent good health, of normal iron status and of high socioeconomic level. Absorption studies used ferric glycinate labeled intrinsically during the synthesis process of this compound as a tracer. In two groups of 15 subjects, iron bioavailability of a milk fortified with 6 mg of elemental iron as ferric glycinate (study 1) and 15 mg elemental iron as ferric glycinate (study 2) was studied. On day 1, the subjects received 250 ml of milk fortified with ferric glycinate labeled with 74 kBq of 55 Fe, and on day two 50 ml of a reference dose of 60 mg elemental iron/L as ferrous ascorbate. The iron bioavailability of the reference dose of ferrous ascorbate was similar in both groups of subjects, 16.5% and 16.4% in study 1 and 2 respectively. Iron absorption of ferric glycinate given with milk in a concentration of 6 or 15 mg/l of elemental iron was not significantly different (5.4% and 4.0% respectively). When iron absorption was standardized to 40% absorption of reference dose, the corresponding percentages of iron absorption were 13.1% and 9.6% for milk fortified with 6 and 15 mg of iron/L respectively. There was a direct correlation between the absorption of ferrous ascorbate and ferric glycinate (r=0.75, p |
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