Electrochemical deamination of alkoxyamine lactams
| Autor: | Leticia Quintero, Mario González-Perea, Enrique Cruz-Gregorio, Fernando Sartillo-Piscil, Julio Romero-Ibañez, Silvano Cruz-Gregorio, Sylvain Bernès |
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| Rok vydání: | 2020 |
| Předmět: |
Aqueous solution
010405 organic chemistry Organic Chemistry Deamination chemistry.chemical_element 010402 general chemistry Electrochemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Acetic acid chemistry.chemical_compound chemistry Drug Discovery Electrode Carbon |
| Zdroj: | Tetrahedron Letters. 61:152279 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2020.152279 |
| Popis: | An anodic electrochemical deamination of 3-alkoxyamine lactams to 3-hydroxy lactams was developed. The electrochemical transformation was achieved by using reticulated vitreous carbon (RVC) and stainless-steel electrodes in aqueous ethanolic solution of NaOAc. This simple electrochemical procedure represents an ecofriendly alternative to the traditional chemical reductive deamination, which requires of a large excess of Zn (up to 40 equivalents) and acetic acid. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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