Olestra Affects Serum Concentrations of α-Tocopherol and Carotenoids but not Vitamin D or Vitamin K Status in Free-Living Subjects
| Autor: | B. P. Koonsvitsky, D. Y. Jones, M. B. Jones, P. Y. T. Lin, D. A. Cooper, Delia A. Berry, J. E. Jackson |
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| Rok vydání: | 1997 |
| Předmět: |
Prothrombin time
Vitamin medicine.medical_specialty Nutrition and Dietetics Olestra medicine.diagnostic_test Fat substitute medicine.medical_treatment Vitamin E Retinol Medicine (miscellaneous) chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine Tocopheryl acetate Partial thromboplastin time |
| Zdroj: | The Journal of Nutrition. 127:1636S-1645S |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/127.8.1636s |
| Popis: | Normal, healthy, free-living adults ingested either 18 g/d olestra, with or without 1.1 mg tocopheryl acetate/g olestra, or 18 g/d triglyceride placebo, for 16 wk in a double-blind, placebo-controlled study. Serum concentrations of alpha-tocopherol, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin, retinol and cholesterol were measured biweekly. Serum 25-hydroxyvitamin D concentration, prothrombin time, partial thromboplastin time and plasma concentration of functional prothrombin (Simplastin-Ecarin assay) were measured at wk 0, 8 and 16. Relative to the placebo group, serum alpha-tocopherol concentration was reduced 6% for the group given 18 g/d olestra. Addition of tocopheryl acetate to olestra partially offset the effect of olestra. For the group given 18 g/d olestra plus 1.1 mg tocopheryl acetate/g olestra, serum alpha-tocopherol concentration was 4% less than the placebo value. Olestra reduced serum concentration of beta-carotene by 27%; the other carotenoids were similarly affected. Serum cholesterol concentration was reduced approximately 4.5% in the olestra groups, relative to placebo, but the differences were not significant. Serum triglycerides, serum 25-hydroxyvitamin D, prothrombin time, partial thromboplastin time or the plasma concentration of under-gamma-carboxylated prothrombin were unaffected by olestra. Clinical observations and laboratory measures indicated no health-related effects of olestra; mild-to-moderate transient gastrointestinal symptoms such as bloating, cramping, loose stools and diarrhea were reported by all groups. |
| Databáze: | OpenAIRE |
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