A Homogeneous Method for the Conveniently Scalable Palladium- and Nickel-Catalyzed Cyanation of Aryl Halides
| Autor: | Julian Egger, Finn Burg, Nicolas Guimond, Johannes Deutsch |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
010405 organic chemistry
Chemistry Ligand Aryl Organic Chemistry chemistry.chemical_element Halide Cyanation 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Nickel Ferrocene Organic chemistry Physical and Theoretical Chemistry Palladium |
| Zdroj: | Organic Process Research & Development. 20:1540-1545 |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.6b00229 |
| Popis: | Homogeneous conditions for the palladium-catalyzed cyanation of aryl halides were developed. This new system features a broad scope of aryl chlorides and bromides, uses 2-propanol or 1-butanol as solvent, and is readily scalable. The same conditions can also provide simple benzonitriles using the recently developed (TMEDA)NiCl(o-tolyl) precatalyst in conjunction with 1,1′-bis(diphenylphosphino)ferrocene (dppf) as a ligand. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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