Role of Cytokines and Mineral Particle Profile in the Development of Coal Workers' Pneumoconiosis as Assessed by Bronchoalveolar Lavage

Autor: J. Shumaker, Diane Schwegler-Berry, N. L. Lapp, Vincent Castranova, Val Vallyathan, S. L. Webe
Rok vydání: 1996
Předmět:
Zdroj: Applied Occupational and Environmental Hygiene. 11:923-927
ISSN: 1521-0898
1047-322X
DOI: 10.1080/1047322x.1996.10389991
Popis: The alveolar macrophage plays a number of important roles in the pathogenesis of silicosis and coal workers' pneumoconiosis (CWP). These roles include phagocytosis of dust particles, release of fibrogenic cytokines, and recruitment and activation of inflammatory cells. Three cytokines, fibronectin, tumor necrosis factor alpha (TNF-α), and interleukin-1β (IL-1β) were measured in the bronchoalveolar lavage fluid (BALF) of controls and asymptomatic coal miners. In addition the alveolar macrophages (AM) from these subjects were analyzed using transmission electron microscopy with X-ray diffraction backscatter in order to determine the number and types of intracellular particles present in these macrophages. Alveolar macrophages from miners contained significantly more particles and silica than controls. Coal miners also exhibited lower levels of TNF-α in lavage fluid. Fibronectin and IL-1β measured in the lavage fluid was not significantly different than controls. This lower TNF-α and lack of elevati...
Databáze: OpenAIRE