Cytotoxic and genotoxic properties of artathomsonine, a new oxoberberine alkaloid from Artabotrys thomsonii (annonaceae)
| Autor: | Céline Mbazoa Djama, Jean Wandji, Véronique Simone Fannang, Sebastian Zühlke, Valery Wilfried Nguemdjo Chimeze, Ezgi Eyluel Bankoglu, Helga Stopper, Ernestine Nicaise Djuidje, Jovita Chi Shirri, Dennis Eckelmann |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Antioxidant biology 010405 organic chemistry medicine.medical_treatment Alkaloid Organic Chemistry Plant Science medicine.disease_cause biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Phytochemical Annonaceae Artabotrys medicine Hydrogen peroxide Genotoxicity |
| Zdroj: | Natural Product Research. 36:2791-2799 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2021.1928117 |
| Popis: | A phytochemical investigation of the liana of Artabotrys thomsonii led to the isolation of a new oxoberberine alkaloid, 2,10-dihydroxy-3,9-dimethoxy-8-oxo-protoberberine (7), along with six known compounds. Their chemical structures were elucidated by 1 D and 2 D NMR spectroscopic methods and HRESI-MSn data analysis. Compounds 4 and 7 were selected for further in vitro investigations. In accordance with expectations from their chemical structures, compounds 7 and 4 showed a clear antioxidant activity in a cell-free assay, with compound 7 being 7-fold more active than 4. Cytotoxicity, cytostatic and genotoxic effects only occurred at high micromolar concentrations of 50 µM or more. Compound 7 was slightly less effective than compound 4. A low micromolar concentration of 10 µM did not cause any damaging cellular effects but showed potential for a protection against the micronucleus-inducing effect of reactive oxygen species hydrogen peroxide, although not to a significant extent. |
| Databáze: | OpenAIRE |
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