A Convergent Synthesis of Tetracyclic Indole Compounds by a Palladium-Catalyzed Cross-Coupling and Tandem Cyclization Reaction
| Autor: | Toshio Nishikawa, Yoshiki Ono, Keiko Higuchi, Masashi Yamaguchi, Kumi Sugino, Atsuo Nakazaki, Masaatsu Adachi |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Synlett. 34:364-368 |
| ISSN: | 1437-2096 0936-5214 |
| Popis: | A new strategy for the convergent synthesis of the ABCD ring system of indole terpene alkaloids has been developed based on a Sonogashira coupling of an o-iodoaniline (the A ring) with an alkyne bearing the D ring. After a tandem palladium-catalyzed cyclization, the tetracyclic ABCD ring structure found in the terpene indole alkaloids was obtained in good yield. |
| Databáze: | OpenAIRE |
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