Increased YAP1 expression is significantly associated with breast cancer progression, metastasis and poor survival
| Autor: | Mahmood Akhtar Kayani, Kiran Taj, Syeda Kiran Riaz, Namood-E Sahar, Farhan Haq, Natasha Sattar, Muhammad Faraz Arshad Malik, Javeria Qadir, Jahangir Sarwar Khan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
YAP1 Cancer Research Hippo signaling pathway business.industry Cancer General Medicine medicine.disease medicine.disease_cause Metastasis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer Real-time polymerase chain reaction Oncology 030220 oncology & carcinogenesis medicine Cancer research Immunohistochemistry business Carcinogenesis |
| Zdroj: | Future Oncology. 17:2725-2734 |
| ISSN: | 1744-8301 1479-6694 |
| DOI: | 10.2217/fon-2020-1080 |
| Popis: | YAP1 plays a key role as a transcriptional coactivator in the Hippo pathway. Based on conflicting reports regarding YAP1 function in cancer, this study discerned its role in breast carcinogenesis. First, a systematic review of salient breast cancer studies targeting YAP1 dysregulation was performed. Additionally, freshly excised tumor specimens of approximately 200 breast cancer patients were processed for quantification of YAP1 expression at mRNA and protein levels using quantitative PCR and immunohistochemistry, respectively. YAP1 expression was nine folds higher in tumors versus controls and significantly associated with metastasis (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|