Collagen Induces Normal Signal Transduction in Platelets Deficient in CD36 (Platelet Glycoprotein IV)

Autor:	James L. Daniel, Strouse R, Carol Dangelmaier, J B Smith
Rok vydání:	1994
Předmět:	biology Chemistry CD36 Tyrosine phosphorylation Hematology Serotonin secretion Cell biology chemistry.chemical_compound parasitic diseases biology.protein Platelet CD36 antigen Platelet activation Signal transduction Tyrosine kinase
Zdroj:	Thrombosis and Haemostasis. 71:353-356
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1642442
Popis:	SummaryThe receptor involved in platelet activation by collagen has not been identified. Platelet glycoprotein IV, now known as CD36, has been implicated in interaction with collagen and also been shown to be associated with intracellular tyrosine kinases. In order to investigate the possible role of collagen-mediated signal transduction via CD36, platelets were obtained from a donor that were deficient in CD36. The collagen-induced intracellular mobilization of Ca2+ in the CD36 deficient cells was of the same magnitude as that seen in platelets from normal donors. In addition, serotonin secretion did not appear to be impaired. Tyrosine phosphorylation was also comparable between the CD36-deficient and normal platelets. Thus, it is unlikely that CD36 plays a major role in collagen-dependent platelet signal transduction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c652bf23ef25881c3c82f575ed58c45c https://doi.org/10.1055/s-0038-1642442 Zobrazit plný text záznamu