Cyclization of 1,1-Disubstituted Alkenes to Cyclopentenes

Autor: Douglass F. Taber, and Timothy D. Neubert, Thomas E. Christos, Dolly Batra
Rok vydání: 1999
Předmět:
Zdroj: The Journal of Organic Chemistry. 64:9673-9678
ISSN: 1520-6904
0022-3263
Popis: A general method for the cyclization of an unactivated 1,1-disubstituted alkene such as 1 to the corresponding cyclopentene 5 is described. Bromination followed by the addition of strong base in the same pot gave the vinyl bromide 3, which reacted further in situ to give the alkylidene carbene 4. This then inserted 1,5 into a C−H bond to give the cyclopentene 5.
Databáze: OpenAIRE