Dual-targeted biodegradable micelles for anticancer drug delivery
| Autor: | Janusz Kasperczyk, Adam Wilczok, Monika Musiał-Kulik, Katarzyna Jelonek, Małgorzata Latocha, Alicja Zajdel, Aleksander Foryś |
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| Rok vydání: | 2019 |
| Předmět: |
Drug
Materials science Mechanical Engineering media_common.quotation_subject 02 engineering and technology Pharmacology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Micelle In vitro 0104 chemical sciences chemistry.chemical_compound Paclitaxel chemistry Mechanics of Materials Critical micelle concentration Drug delivery General Materials Science 0210 nano-technology Cytotoxicity Ethylene glycol media_common |
| Zdroj: | Materials Letters. 241:187-189 |
| ISSN: | 0167-577X |
| DOI: | 10.1016/j.matlet.2019.01.081 |
| Popis: | Polymeric micelles have been widely studied and developed for targeted delivery of cytostatic drugs. However, due to heterogeneity of tumor cells, targeting efficiency may be enhanced by using different types of targeting agents on the same drug delivery system. The aim of the study was to obtain and characterize paclitaxel-loaded biodegradable poly( l -lactide)-co-poly(ethylene glycol) (PLA-PEG) micelles functionalized with folic acid and biotin. The developed dual targeted micelles show low critical micelle concentration, high loading capacity of paclitaxel and prolonged in vitro drug release. The cytotoxicity of paclitaxel-loaded micelles was confirmed against folate- and biotin-receptor positive OVCAR3 cells, which indicates their usefulness for targeted delivery of cytostatic drug. |
| Databáze: | OpenAIRE |
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