Oxovanadium(IV) Schiff Base Complex Derived From Phenylalanine Analogue Containing 2,3-Diaminopropionic Acid (DAP): Synthesis, Computational Study, and Biological Evaluation

Autor:	GL Fang, Dongqi Wang, Y Liu, X Yang, JJ Wang, Lei Wei, YH Zhang, WJ Yang, JQ Xue, ZQ Gao
Rok vydání:	2014
Předmět:	Schiff base Ligand Stereochemistry Phenylalanine Inorganic Chemistry Metal chemistry.chemical_compound chemistry Salicylaldehyde visual_art visual_art.visual_art_medium Physical and Theoretical Chemistry Antibacterial activity 2 3-Diaminopropionic acid Natural bond orbital
Zdroj:	Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry. 45:455-467
ISSN:	1553-3182 1553-3174
DOI:	10.1080/15533174.2013.841205
Popis:	Reduced Schiff base ligand by condensation of phenylalanine analogue containing 2,3-diaminopropionic acid (DAP) with salicylaldehyde and its oxovanadium(IV) complex have been prepared. Chemical and structural properties were fully characterized. Density functional theory was used to pin down the structure combined with IR. The natural bond orbital analysis and energy calculations indicate that tetracoordinated complex of R-type is the most probable structure where vanadium atom is coordinated to 2 x O-phenolate and 2 x N-imine of the ligand. By biological evaluation, the metal complex exhibits antibacterial activity against four bacterial strains and antitumor activity against two tumor cell lines.
Databáze:	OpenAIRE
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